PRSice: Polygenic Risk Score software

PRSice: Polygenic Risk Score software

SUMMARY A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS can also be used to establish the presence of a genetic signal in un...

Schizophrenia polygenic risk score and psychotic risk detection.

Predicting Alzheimer's disease: a polygenic hazard score.

the genetic factors that influence the development of alzheimer’s disease (ad) have been the subject of large international collaborative studies in recent years involving many thousands of patients and controls. genome wide association screens (gWas) have produced large datasets which include not only genetic linkage information but also clinical material such as age of disease onset and, in s...

Cardiovascular Score Card: Risk Factor Analysis Software

At this point, each aspect of the graph can be individually modified in some way. Choices governing color, tone, texture, grid display, cell spacing, row and column orientation, label dimension and orientations, character fonts, and other items may be approached by the preset options or the custom route. Preset options are coordinated schemes which generally display the graph well; however, the...

An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis

BACKGROUND Polygenic risk scores (PRSs) have successfully summarized genome-wide effects of genetic variants in schizophrenia with significant predictive power. In a clinical sample of first-episode psychosis (FEP) patients, we estimated the ability of PRSs to discriminate case-control status and to predict the development of schizophrenia as opposed to other psychoses. METHODS The sample (44...